Impact of icosapent ethyl on CSF NULISA vascular, metabolic, and AD biomarkers in cognitively unimpaired Veterans at risk for dementia
In this cohort of cognitively unimpaired VA-eligible Veterans, IPE did not alter NULISA CSF biomarkers of vascular and metabolic health or AD pathology (pTau-217). While EPA has previously been shown to improve VEGF-mediated inflammatory and atherogenic processes, further studies are needed to clarify the potential role of IPE or other omega-3 fatty acids to alter AD risk through vascular risk modification.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Richard J. Chappell (ORCID: https://orcid.org/0000-0002-3891-0881)
- Kate Cronin
- Elena Beckman
- Allison C Eierman
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Aleshia Cole
- Hannah Zylstra
- Cynthia M. Carlsson
- Henrik Zetterberg
- Carey E. Gleason
- Carol A. Van Hulle
Institutions
- University of Wisconsin–Madison (US)
- Hong Kong Science and Technology Parks Corporation (HK)
- Geriatric Research Education and Clinical Center (US)
- UK Dementia Research Institute (GB)
- William S. Middleton Memorial Veterans Hospital (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_106943
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00