Functional Near‐Infrared Spectroscopy Reveals Lecanemab‐Induced Neural Changes During the Clock Drawing Test in Alzheimer's Disease

Lecanemab therapy may induce notable changes in brain functional connectivity and neural activation patterns in AD, as evidenced by fNIRS during the CDT. The observed increase in frontal-occipital FC may indicate improved network coordination, whereas the decreased parietal-frontal connectivity could reflect compensatory reorganization. These findings underscore the potential of fNIRS for monitoring treatment-related neuronal changes in AD and warrant validation in larger cohorts.