Effect of Food Consumption on the Pharmacokinetics of ACP‐204, a Novel 5‐HT <sub>2A</sub> Receptor Selective Antagonist/Inverse Agonist
The criterion for bioequivalence for fed vs fasted was within the bioequivalence boundary for C<sub>max</sub> and AUC, indicating that food has no meaningful effect on the rate or extent of ACP-204 absorption. A single 60-mg dose of ACP-204 was safe and generally well tolerated, with no unexpected safety findings.
Authors
- Bryan Dirks (ORCID: https://orcid.org/0000-0001-6472-1606)
- Mona Darwish
- Sanjeev Pathak (ORCID: https://orcid.org/0000-0003-1565-2223)
- B. Raether
- Xiaoshu Feng
Institutions
- Acadia Pharmaceuticals (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_105644
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00