Stearoyl‐CoA desaturase inhibition leads to fatty acids normalization and improves dendritic spine density in the hippocampus of 5xFAD mouse model
These data demonstrate that SCD inhibitor treatment in a second AD mouse model, the more aggressive 5xFAD model, has beneficial effects on FA alterations and hippocampal dendritic spines. These findings add to accumulating data supporting SCD inhibition as a promising novel therapeutic target for AD.
Authors
- Karl J. L. Fernandes (ORCID: https://orcid.org/0000-0002-6236-8770)
- Annick Vachon
- Marta Turri (ORCID: https://orcid.org/0000-0001-8293-7195)
- Anne Aumont
- Myriam Aubin
- Mélanie Plourde
- Laura K Hamilton
Institutions
- Université de Sherbrooke (CA)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Health and Social Services Centre University Institute of Geriatrics of Sherbrooke (CA)
- Q & T Research (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_100935
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00