Symptomatic diversity in the logopenic variant of Primary Progressive Aphasia

While profiles with the core characteristics of lvPPA were identified, discrepancies among participants, such as the differences in performance between P1, P2, and P6, highlight the symptomatic diversity within lvPPA. Additionally, participants like P4, despite retaining the core characteristics of lvPPA, exhibited secondary features more aligned with semantic deficits, suggesting the existence of mixed profiles, as proposed by Mazzeo et al. (2024). These findings underscore the importance of detailed profile analysis to improve diagnostic accuracy in PPA.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_106008
Primary Topic
Neurobiology of Language and Bilingualism
Type
article
Field-Weighted Citation Impact
0.00
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article

Symptomatic diversity in the logopenic variant of Primary Progressive Aphasia

Leticia Vivas, Axel Fernández‐Zaionz
Alzheimer s & Dementia
Neurobiology of Language and Bilingualism
article

Symptomatic diversity in the logopenic variant of Primary Progressive Aphasia

Leticia Vivas, Axel Fernández‐Zaionz
article en

Abstract

While profiles with the core characteristics of lvPPA were identified, discrepancies among participants, such as the differences in performance between P1, P2, and P6, highlight the symptomatic diversity within lvPPA. Additionally, participants like P4, despite retaining the core characteristics of lvPPA, exhibited secondary features more aligned with semantic deficits, suggesting the existence of mixed profiles, as proposed by Mazzeo et al. (2024). These findings underscore the importance of detailed profile analysis to improve diagnostic accuracy in PPA.

Alzheimer s & DementiaVol. 21(S3)
National University of Mar del Plata (AR), Centro Científico Tecnológico Mar del Plata (AR)
Quality Education
Openalex Percentile: Top 32%
Neurobiology of Language and Bilingualism
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