Self‐reported sleep duration in relation to brain MRI measures across pre‐symptomatic continuum in older adults age 90+
In this exploratory analysis long sleep is related to lower SWM volume in amyloid negative, and to lower SGM volume in amyloid positive older adults with normal cognition. In the amyloid negative group long sleep, which could indicate poor sleep quality, may be related to vascular pathologies, which in turn, affect white matter integrity. In amyloid positive group lower gray matter volume might be more related to the amyloid accumulation.
Authors
- Bryce A. Mander (ORCID: https://orcid.org/0000-0002-0831-7980)
- Zeinah Al‐Darsani
- Davis C. Woodworth (ORCID: https://orcid.org/0000-0002-6256-857X)
- María M. Corrada (ORCID: https://orcid.org/0000-0002-8168-8593)
- Claudia H. Kawas (ORCID: https://orcid.org/0000-0001-9577-230X)
- Zarui A. Melikyan (ORCID: https://orcid.org/0000-0002-8495-5546)
- Michael A. Yassa (ORCID: https://orcid.org/0000-0002-8635-1498)
- Seyed ahmad Sajjadi (ORCID: https://orcid.org/0000-0001-5003-7889)
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_104049
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00