Distinct patterns of cortical atrophy characterize AD pathology

A significant percentage (25%) of patients with memory impairment present with isolated Parietal Atrophy which displays a distinctive set of biological, imaging and clinical features. Lower Tau accumulation in the Parietal variant may underlie its relatively milder cognitive impairment, reinforcing the role of Tau as the primary driver of phenotypic differences between the two groups. This could be highly relevant in clinical practice to ensure precise subcategorization of patients with cognitive impairment, addressing them to the most appropriate targeted therapy.