Gene‐expression contributions to specific and shared regional vulnerabilities to amyloid, tau, and neurodegeneration in Alzheimer's disease

Selective AD vulnerabilities were differently related to specific gene expression and molecular-biological properties, with a large set of genes associated with amyloid accumulation and a subset of genes conferring additional vulnerability to downstream tau. Our findings suggest that the spatial and temporal decoupling between amyloid deposition, tau deposition and neurodegeneration is explained by differential genetic expression but that shared mechanisms link upstream amyloid with subsequent tau pathology and loss of neuronal integrity.