Epigenetic signatures of plasma protein abundance are associated with longitudinal brain and cognitive trajectories in older adults
Our analyses revealed several epigenetic indicators of circulating protein abundance (e.g., a DNAm measure of MMP12) to be strongly associated with trajectories of cognitive aging and MRI-defined neurodegeneration.
Authors
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Michael R. Duggan (ORCID: https://orcid.org/0000-0002-1029-4423)
- Diefei Chen (ORCID: https://orcid.org/0000-0002-9195-3311)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Zenobia Moore
- Shannon M. Drouin (ORCID: https://orcid.org/0000-0001-8767-5884)
- Cassandra Blew
- Cassandra M Joynes
- Pei‐Lun Kuo
- Susan M. Resnick
- Guray Erus
Institutions
- Johns Hopkins University (US)
- Institute on Aging (US)
- National Institute on Aging (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103678
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00