Carbonic Anhydrase-IX Is a Specific and Sensitive Theragnostic Target for Imaging and Radioimmunotherapy in Metastatic Colorectal Cancer

Our results demonstrate that CA-IX is a relevant target for a theragnostic strategy in mCRC, and provide the first demonstration in clinically-relevant models of metastasis that radiolabeled girentuximab can be used as a scouting agent to stratify and monitor mCRC patients and as a therapeutic alternative for patients with CA-IX-expressing tumors.

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Publication Details

Journal
Gastro Hep Advances
Published
2025-12-26
DOI
https://doi.org/10.1016/j.gastha.2025.100871
Primary Topic
Enzyme function and inhibition
Type
article
Field-Weighted Citation Impact
0.00
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article

Carbonic Anhydrase-IX Is a Specific and Sensitive Theragnostic Target for Imaging and Radioimmunotherapy in Metastatic Colorectal Cancer

Wagner Ra, Pd Roselt, P.S. Donnelly, A. Noor et al.
Gastro Hep Advances
Enzyme function and inhibition
article

Carbonic Anhydrase-IX Is a Specific and Sensitive Theragnostic Target for Imaging and Radioimmunotherapy in Metastatic Colorectal Cancer

Wagner Ra, Pd Roselt, P.S. Donnelly, A. Noor, S. Lee, B. Blyth, J.K. Van Zuylekom, A.G. Heriot, B. Loveday, T. Vu, K. Waldeck, F. Hollande, D. Swaroop, J. Smith
article en

Abstract

Our results demonstrate that CA-IX is a relevant target for a theragnostic strategy in mCRC, and provide the first demonstration in clinically-relevant models of metastasis that radiolabeled girentuximab can be used as a scouting agent to stratify and monitor mCRC patients and as a therapeutic alternative for patients with CA-IX-expressing tumors.

Gastro Hep AdvancesVol. 5(3)
The University of Melbourne (AU), Peter MacCallum Cancer Centre (AU), Victorian Curriculum and Assessment Authority (AU), Victorian Comprehensive Cancer Centre (AU)
Good health and well-being
Openalex Percentile: Top 36%
Enzyme function and inhibition
DOIOpen Access PDFOpenAlex
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