Hesperidin Attenuates Lead‐Induced Cognitive Impairment via TFEB Activation: Implications for Neuroprotection in Alzheimer’s Disease

These findings suggest that hesperidin alleviates lead-induced cognitive dysfunction by mitigating oxidative stress, inflammation, and neuronal damage while enhancing mitochondrial function, potentially through TFEB activation. This study highlights the therapeutic potential of hesperidin in heavy metal-induced neurotoxicity and cognitive disorders.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_104758
Primary Topic
Heavy Metal Exposure and Toxicity
Type
article
Field-Weighted Citation Impact
0.00
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article

Hesperidin Attenuates Lead‐Induced Cognitive Impairment via TFEB Activation: Implications for Neuroprotection in Alzheimer’s Disease

Pratham Gautam, Varinder Singh
Alzheimer s & Dementia
Heavy Metal Exposure and Toxicity
article

Hesperidin Attenuates Lead‐Induced Cognitive Impairment via TFEB Activation: Implications for Neuroprotection in Alzheimer’s Disease

Pratham Gautam, Varinder Singh
article en

Abstract

These findings suggest that hesperidin alleviates lead-induced cognitive dysfunction by mitigating oxidative stress, inflammation, and neuronal damage while enhancing mitochondrial function, potentially through TFEB activation. This study highlights the therapeutic potential of hesperidin in heavy metal-induced neurotoxicity and cognitive disorders.

Alzheimer s & DementiaVol. 21(S5)
Maharaja Ranjit Singh Punjab Technical University (IN)
Openalex Percentile: Top 33%
Heavy Metal Exposure and Toxicity
DOIOpen Access PDFOpenAlex
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Hesperidin Attenuates Lead‐Induced Cognitive Impairment via TFEB Activation: Implications for Neuroprotection in Alzheimer’s Disease — Pratham Gautam, Varinder Singh · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS