Pulse pressure is associated with Alzheimer's disease pathology and cognitive decline

These findings underscore the importance of arterial stiffness as a contributor to AD pathology and lower cognition, particularly in individuals with genetic susceptibility. By revealing how PP interacts with APOE4 to influence tau deposition, this study emphasizes the need for targeted interventions addressing vascular health to mitigate AD progression. Future research should further explore mechanisms linking vascular health and AD biomarkers to refine preventative strategies.