The association of white‐matter integrity with depression‐ symptoms among middle‐aged adults at high risk for Alzheimer's disease and related disorders
In cognitively normal individuals at increased ADRD risk, disrupted white matter integrity in specific tracts is associated with more depressive symptoms already in midlife. These findings highlight the potential of white matter alterations as early biomarkers of neurodegeneration, creating opportunities for timely intervention and prevention.
Authors
- Ithamar Ganmore (ORCID: https://orcid.org/0000-0003-3760-680X)
- Ganit Almog
- Tamar Shamir
- Livny Abigail
- Adar Matatov
- Shlomit Zorani (ORCID: https://orcid.org/0000-0002-7027-2103)
- Tal Niv
- Shiraz Vered
- Laili Soleimani
- Joseph Azuri
- Ramit Ravona‐Springer
- Galit Weinstein
- Michal Schnaider Beeri
Institutions
- Rutgers, The State University of New Jersey (US)
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- Maccabi Healthcare Services (IL)
- Alzheimer's Association of Israel (IL)
- University of Haifa (IL)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_105717
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00