Integrated multi-omics unravels solanesol’s multi-organ protection mechanisms against insulin resistance in type 2 diabetic mice
Solanesol demonstrates multi-organ protective effects through gut microbiota-metabolite crosstalk and hepatic lipid/redox homeostasis regulation. Its multi-target efficacy and oral bioavailability position it as a novel, clinically translatable candidate for T2DM management.
Authors
- Jiaqi Fu
- Zhangying Wang
- Wenji Zhang (ORCID: https://orcid.org/0000-0001-7783-8213)
- Wenli Cheng
- Wenjuan Zhang
- Jingbo Zhou
- Yibo Chen
- Ruidong Zeng
Institutions
- Jinan University (CN)
- Rice Research Institute (CN)
- Key Laboratory of Guangdong Province (CN)
- Guangdong Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.025
- Primary Topic
- Coenzyme Q10 studies and effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00