Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced pulmonary endothelial barrier dysfunction by activating TXNDC5
Our findings demonstrate that ER stress-induced TXNDC5 upregulation exacerbates LIRI by impairing HSP90/eNOS-dependent endothelial function. ER stress-TXNDC5 signaling is a mechanistically distinct and potential target in LIRI.
Authors
- Pu Chen (ORCID: https://orcid.org/0000-0002-6857-2211)
- Heng Gu
- Shiqian Huang
- Shanglong Yao
- Yangqi Chu
- Yiyi Yang
- Yun Lin
- Yangyang Ge
- Yu Wang
- Lin Li Chen
Institutions
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.039
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00