Longitudinal Studies of Blood‐Based Biomarkers for Dementia in Primary Care: A Systematic Review and Meta‐Analysis

Longitudinal BBM models demonstrate robust predictive ability for incident dementia and cognitive decline, even in the context of high heterogeneity across primary care and community settings. Early phases of disease, offer opportunities for stratified prediction. However, large observational trials in primary care are required to validate these findings, refine and optimise models for real-world deployment.