Early Detection and High‐Risk Monitoring of Cell‐Based Genetic Subtypes Using Plasma Biomarkers

Plasma protein levels from at-risk individuals for cell-based genetic subtypes exhibited considerable enrichment for neuroinflammatory proteins, indicating potential as genetic-subtype-specific biomarkers. These results highlight plasma biomarkers as cost-effective tools for early detection in genetically at-risk individuals of specific brain cell types.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103575
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
0.00
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article

Early Detection and High‐Risk Monitoring of Cell‐Based Genetic Subtypes Using Plasma Biomarkers

Nathan Sahelijo, Gyungah R Jun, Daniel Goldstein
Alzheimer s & Dementia
Single-cell and spatial transcriptomics
article

Early Detection and High‐Risk Monitoring of Cell‐Based Genetic Subtypes Using Plasma Biomarkers

Nathan Sahelijo, Gyungah R Jun, Daniel Goldstein
article en

Abstract

Plasma protein levels from at-risk individuals for cell-based genetic subtypes exhibited considerable enrichment for neuroinflammatory proteins, indicating potential as genetic-subtype-specific biomarkers. These results highlight plasma biomarkers as cost-effective tools for early detection in genetically at-risk individuals of specific brain cell types.

Alzheimer s & DementiaVol. 21(S2)
Boston University (US)
Openalex Percentile: Top 36%
Single-cell and spatial transcriptomics
DOIOpen Access PDFOpenAlex
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Early Detection and High‐Risk Monitoring of Cell‐Based Genetic Subtypes Using Plasma Biomarkers — Nathan Sahelijo, Gyungah R Jun, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS