Characterizing the TICAM1 interaction network to target the innate immune response in AD
Targeting the TICAM1 protein-protein interactions presents a novel method for regulating the innate immune response. We have identified key PPI and developed screening assays suitable for screening small molecule inhibitors as a first step in drug development addressing the innate immune response in AD. This work has been collected as part of the Emory-Sage-SGC-Jax TREAT-AD Center.
Authors
- Yuhong Du (ORCID: https://orcid.org/0000-0001-5073-2048)
- Gregory A. Cary (ORCID: https://orcid.org/0000-0003-3573-5229)
- Elizabeth Zoeller (ORCID: https://orcid.org/0000-0001-9588-3114)
- Haian Fu
- Hyemin Lee
- Allan I. Levey
- Andrey A Ivanov
Institutions
- Emory University (US)
- Jackson Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_101233
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University