Tau Cognitive Mismatch in Alzheimer's Disease Predicts Presence of Co‐Pathology and Diverging Disease Trajectory
Tau-cognitive mismatch identifies vulnerable individuals who are more likely to have α-synuclein co-pathology and neurodegeneration patterns that overlap with LATE. The plasma-based models also successfully identified similar vulnerable individuals in an independent dataset.
Authors
- Magdalena Korecka (ORCID: https://orcid.org/0000-0003-3129-8295)
- Ilya M. Nasrallah (ORCID: https://orcid.org/0000-0003-2346-7562)
- L. Shaw
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- J Detré
- Long Xie
- Emily McGrew
- Alice S Chen-Plotkin
- Dawn Mechanic‐Hamilton
- Katheryn A. Q. Cousins
- Thomas F. Tropea
- Paul A. Yushkevich
- Eddie B Lee
- Christopher D. Brown
- Sandhitsu R. Das
- Corey T. McMillan
Institutions
- Siemens (United States) (US)
- Siemens Healthcare (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104485
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00