Designed peptide increases clearance of Aβ toxic oligomers and inhibits plaque formation
SOBIN-01 is a highly specific peptide that targets the α-sheet conformation of Aβ and leads to enhanced phagocytosis by microglia and macrophage cells. In vivo SOBIN-01 demonstrated a significant reduction in plaque area in Tg2576 AD mice. Together, these data suggest that SOBIN-01 targets and stimulates the clearance of Aβ toxic oligomers.
Authors
- Valerie Daggett (ORCID: https://orcid.org/0000-0002-5116-6102)
- Koya Yakabi (ORCID: https://orcid.org/0000-0002-9429-0680)
- Chandresh R. Gajera (ORCID: https://orcid.org/0000-0002-4638-2097)
- Emma Breyak
- Gil Block
- Carolyn Tallon
- Sebastien Pradel
- Jeff Posakony
Institutions
- Altera (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_104011
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00