Advanced MRI biomarkers for efficient clinical trial designs in Progressive Supranuclear Palsy (PSP)

The integration of advanced MRI processing techniques, including volumetric and dMRI analyses, enhances sensitivity to brain changes in PSP, significantly reducing sample size requirements for clinical trials. These findings underscore the importance of selecting robust imaging biomarkers and analysis methods to improve trial efficiency and accelerate therapeutic development for PSP.

Authors

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_102985
Primary Topic
Advanced Neuroimaging Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00
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article

Advanced MRI biomarkers for efficient clinical trial designs in Progressive Supranuclear Palsy (PSP)

Jean‐Philippe Coutu, Alex Zijdenbos, Simone P. Zehntner, Felix Carbonell et al.
Alzheimer s & Dementia
Advanced Neuroimaging Techniques and Applications
article

Advanced MRI biomarkers for efficient clinical trial designs in Progressive Supranuclear Palsy (PSP)

Jean‐Philippe Coutu, Alex Zijdenbos, Simone P. Zehntner, Felix Carbonell, Barry J Bedell
article en

Abstract

The integration of advanced MRI processing techniques, including volumetric and dMRI analyses, enhances sensitivity to brain changes in PSP, significantly reducing sample size requirements for clinical trials. These findings underscore the importance of selecting robust imaging biomarkers and analysis methods to improve trial efficiency and accelerate therapeutic development for PSP.

Alzheimer s & DementiaVol. 21(S2)
Openalex Percentile: Top 31%
Advanced Neuroimaging Techniques and Applications
DOIOpen Access PDFOpenAlex
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Advanced MRI biomarkers for efficient clinical trial designs in Progressive Supranuclear Palsy (PSP) — Jean‐Philippe Coutu, Alex Zijdenbos, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS