Unicystic ameloblastoma: Systematic review of clinico-pathologic features and treatment outcomes in infants, children and young adults

The study aimed to assess the outcomes of literature published between 2012 to 2022 and gather information about clinical, radiological, histopathological characteristics and treatment outcomes of unicystic ameloblastoma in infants, children, and young adults. A total of 325 publications were assessed using computer and manual approaches. A structured literature search was carried out utilizing predefined criteria. An assessment and critical appraisal were done in three distinct rounds. In total, 34 articles describing 36 cases satisfied the selection criteria and were thus included in the final review. Unicystic ameloblastoma was most commonly presented as swelling found on the mandibular posterior region exhibiting unilocular radiolucency. Maximum cases were of the mural type of histopathologic variant. According to the result of this study, conservative treatment appears to be more effective in younger age groups due to reduced reported recurrence rate.