The Therapeutic Role of Monocytes in Alzheimer's Disease: Effects on Vascular Amyloid‐Beta Transport

These findings highlight NOD2 as a promising therapeutic target for modulating innate immune responses to enhance AB clearance. Additionally, the combination of NOD2 activation and glucocorticoids offers a novel dual approach to AD and CAA treatments by promoting both immune and BBB-mediated clearance of AB while reducing inflammation.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_101318
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

The Therapeutic Role of Monocytes in Alzheimer's Disease: Effects on Vascular Amyloid‐Beta Transport

Nataly Laflamme, Ayanna Arneaud, Serge Rivest
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

The Therapeutic Role of Monocytes in Alzheimer's Disease: Effects on Vascular Amyloid‐Beta Transport

Nataly Laflamme, Ayanna Arneaud, Serge Rivest
article en

Abstract

These findings highlight NOD2 as a promising therapeutic target for modulating innate immune responses to enhance AB clearance. Additionally, the combination of NOD2 activation and glucocorticoids offers a novel dual approach to AD and CAA treatments by promoting both immune and BBB-mediated clearance of AB while reducing inflammation.

Alzheimer s & DementiaVol. 21(S5)
Université Laval (CA)
Good health and well-being
Openalex Percentile: Top 33%
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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The Therapeutic Role of Monocytes in Alzheimer's Disease: Effects on Vascular Amyloid‐Beta Transport — Nataly Laflamme, Ayanna Arneaud, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS