Targeting Neuroinflammation by Bioreactive Nanoparticles for Early Detection and Intervention of Alzheimer’s Disease
The results suggest that TP-MDNP can enable MRI detection of neuroinflammation and reduce neurodegeneration pathogenetic factors such as ROS, hypoxia, and p-tau in AD mouse brains. References 1. Zhang W, et al. Sig Transduct Target Ther 2023;8, 267. 2. He C, et al. Nano Today. 2020;35:100965. 3. Park E,. et al. Advanced Science. 2023 Apr;10(12):2207238. 4. Park E, et al. Biomaterials. 2025 Jan 24:123142.
Authors
- Jeffrey T. Henderson (ORCID: https://orcid.org/0000-0001-7636-2604)
- Elliya Park
- R Rajakumar
- Shudi Huang
- Liting Wang (ORCID: https://orcid.org/0009-0001-9307-4193)
- Chunsheng He
- Paul E Fraser
- Xiao Yu Wu
- Azhar Z. Abbasi
Institutions
- University of Toronto (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_104173
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00