Diagnostic performance of MK and Flortaucipir tau PET for the biological staging of Alzheimer disease
Our results support that AA-2024 biological and clinical stages show similar clinical-biological concordance using either Flortaucipir or MK-6240, although this can vary based on methods tested in the study. The MBI and SCD clinical subgroups showed no difference of pathological burden to clinical stage 1, while SOCD transitional stage showed higher burden compared to stage 1.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Madeleine Bloomquist (ORCID: https://orcid.org/0009-0009-0556-9478)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Belén Pascual (ORCID: https://orcid.org/0000-0002-4467-7406)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Emma Patrice Ruppert (ORCID: https://orcid.org/0000-0001-5877-5472)
- Matheus Scarpatto Rodrigues (ORCID: https://orcid.org/0000-0002-7794-6588)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Hussein Zalzale
- Markley Silva Oliveira (ORCID: https://orcid.org/0000-0002-0631-4065)
- David Soleimani‐Meigooni
- Pampa Saha (ORCID: https://orcid.org/0000-0002-4926-9081)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Hwamee Oh (ORCID: https://orcid.org/0000-0003-1156-5704)
- Pamela C.L. Ferreira
- Livia Amaral
- Guilherme Povala
- Carolina Soares
- Rayan Mroué
- Andreia Rocha
- Marina Scop Madeiros
- Brian A. Gordon
- Pedro Rosa‐Neto
Institutions
- Universitat Autònoma de Barcelona (ES)
- Houston Methodist (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Hospital de Sant Pau (ES)
- Mayo Clinic in Arizona (US)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_107236
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00