Baseline Association Between Remotely‐measured Cognitive Function and Blood Pressure in a Large, Multicenter Pragmatic Hybrid Effectiveness‐Implementation Trial
Higher systolic BP is associated with poorer performance in semantic fluency and verbal learning, independent of age and sex, yet it is not associated with global cognitive function. These findings suggest that hypertension may selectively impact specific cognitive domains, particularly those related to language and memory. Furthermore, these abilities are often affected early in AD. Future analyses will explore whether lowering BP can slow cognitive decline in the broad patient population seen in the primary care setting.
Authors
- Adam C. Parks (ORCID: https://orcid.org/0000-0002-7159-688X)
- Molly A. Conroy
- Diego R. Mazzotti (ORCID: https://orcid.org/0000-0003-3924-9199)
- Kate Young (ORCID: https://orcid.org/0000-0003-2680-013X)
- Jeffrey Murray Burns (ORCID: https://orcid.org/0000-0001-7609-8954)
- Sravani Chandaka
- Mark A. Supiano (ORCID: https://orcid.org/0000-0002-5438-5087)
- Xing Song
- Jonathan D Mahnken
- Aditi Gupta
Institutions
- University of Utah (US)
- University of Kansas Medical Center (US)
- University of Missouri (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70858_104060
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00