Linking resting‐state gamma activity to associative memory: a potential biomarker for cognitive aging and Alzheimer's Disease

The correlation between increased temporal s-γ and improved accuracy confirms temporal lobe involvement in the consolidation and retrieval of associative memories (Mayes et al., 2007), consistent with reports of reduced gamma power in the medial temporal lobe in AD patients (Babiloni et al., 2020). Moreover, increased frontal f-γ activity suggests greater reliance on executive control processes, typically located in the prefrontal cortex, facilitating retrieval (Wang et al., 2018). Reduced posterior f-γ activity may indicate a shift from sensory integration to higher-order cognitive processing, with disruptions potentially reflecting imbalanced network dynamics, as observed in AD (Verret et al., 2012). These findings offer novel insights into the neurophysiological mechanisms underlying associative memory, possibly facilitating monitoring and prevention of cognitive decline in populations at risk for AD.