OPRL1 genotypes moderate the association between prosocial effort‐based decision making and apathy in at‐risk older adults
Older adults at risk for AD demonstrate a higher willingness and require smaller rewards to exert effort for prosocial compared to self-serving rewards. Genetic variations in OPRL1 SNPs modulate the relationship between prosocial orientations and apathy, suggesting individuals with specific genetic profiles show reduced apathetic behavior associated with prosocial effort in aging.
Authors
- Maiya R. Geddes (ORCID: https://orcid.org/0009-0000-2371-934X)
- Caitlin Walker (ORCID: https://orcid.org/0000-0003-0977-8276)
- M. Catherine Bennett (ORCID: https://orcid.org/0000-0001-6178-8610)
- Cynthia Picard (ORCID: https://orcid.org/0000-0003-1107-6839)
- Sylvia Villeneuve (ORCID: https://orcid.org/0000-0003-2338-0467)
- Josée Poirier (ORCID: https://orcid.org/0000-0002-1302-869X)
- Garance Barnoin
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Douglas Mental Health University Institute (CA)
- McGill University Health Centre (CA)
- Alzheimer Society of Canada (CA)
- McGill Genome Centre (CA)
- McGill University (CA)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_106007
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00