Multi‐Domain Cognitive Assessment in a Scopolamine‐Induced Mouse Model: Toward a Translational Framework

The scopolamine-induced cognitive impairment model demonstrated domain-specific deficits with task- and dose-dependent treatment responses. These findings emphasize the need for optimization and task refinement to enhance model reliability. Structuring these tasks into a comprehensive multi-domain battery could provide a robust preclinical platform for evaluating potential therapeutics and advancing our understanding of dementia's cognitive complexities.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_106326
Primary Topic
Memory and Neural Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Multi‐Domain Cognitive Assessment in a Scopolamine‐Induced Mouse Model: Toward a Translational Framework

J Yeon Lee, Jinhak Kim, Keun You Kim, Junho Kim et al.
Alzheimer s & Dementia
Memory and Neural Mechanisms
article

Multi‐Domain Cognitive Assessment in a Scopolamine‐Induced Mouse Model: Toward a Translational Framework

J Yeon Lee, Jinhak Kim, Keun You Kim, Junho Kim, Ha Jin Jeong, Euimo Yang, Eosu Kim, Hyunjeong Kim
article en

Abstract

The scopolamine-induced cognitive impairment model demonstrated domain-specific deficits with task- and dose-dependent treatment responses. These findings emphasize the need for optimization and task refinement to enhance model reliability. Structuring these tasks into a comprehensive multi-domain battery could provide a robust preclinical platform for evaluating potential therapeutics and advancing our understanding of dementia's cognitive complexities.

Alzheimer s & DementiaVol. 21(S5)
Yonsei University (KR)
Reduced inequalities
Openalex Percentile: Top 32%
Memory and Neural Mechanisms
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