Multi‐Domain Cognitive Assessment in a Scopolamine‐Induced Mouse Model: Toward a Translational Framework
The scopolamine-induced cognitive impairment model demonstrated domain-specific deficits with task- and dose-dependent treatment responses. These findings emphasize the need for optimization and task refinement to enhance model reliability. Structuring these tasks into a comprehensive multi-domain battery could provide a robust preclinical platform for evaluating potential therapeutics and advancing our understanding of dementia's cognitive complexities.
Authors
- J Yeon Lee
- Jinhak Kim (ORCID: https://orcid.org/0000-0002-7329-4324)
- Keun You Kim (ORCID: https://orcid.org/0000-0001-7192-2828)
- Junho Kim (ORCID: https://orcid.org/0000-0002-7769-910X)
- Ha Jin Jeong (ORCID: https://orcid.org/0000-0003-2722-4453)
- Euimo Yang
- Eosu Kim
- Hyunjeong Kim
Institutions
- Yonsei University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_106326
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00