Kounis Syndrome: An Entity One Should Not Forget

Kounis syndrome is an underreported diagnosis, even though it is a frequent pathology. It is an acute coronary syndrome that can present in the setting of an allergic or an anaphylactic reaction that could be triggered by the use of drugs. We present the case of a patient with a known medical history of drug allergies (but not of anaphylaxis), who presented to the emergency department with complaints of headache. After the administration of a painkiller, she developed hypotension, syncope, elevation of troponin, and transitory changes in the ST segment of the electrocardiogram.

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Publication Details

Journal
Cureus
Published
2025-12-26
DOI
https://doi.org/10.7759/cureus.100128
Primary Topic
Food Allergy and Anaphylaxis Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Kounis Syndrome: An Entity One Should Not Forget

Daniela Marto, Mariana Melani, Jaqueline Silva de Oliveira, Filipa Figueiredo et al.
Cureus
Food Allergy and Anaphylaxis Research
article

Kounis Syndrome: An Entity One Should Not Forget

Daniela Marto, Mariana Melani, Jaqueline Silva de Oliveira, Filipa Figueiredo, Joana Paulo
article en

Abstract

Kounis syndrome is an underreported diagnosis, even though it is a frequent pathology. It is an acute coronary syndrome that can present in the setting of an allergic or an anaphylactic reaction that could be triggered by the use of drugs. We present the case of a patient with a known medical history of drug allergies (but not of anaphylaxis), who presented to the emergency department with complaints of headache. After the administration of a painkiller, she developed hypotension, syncope, elevation of troponin, and transitory changes in the ST segment of the electrocardiogram.

CureusVol. 17(12)
Hospital Prof. Dr. Fernando Fonseca (PT)
Good health and well-being
Openalex Percentile: Top 29%
Food Allergy and Anaphylaxis Research
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