Early & late cerebrovascular biomarkers: Operationalization of cut‐points and temporal progression

We developed cut-points for diffusion MRI markers using classification of VCI based on Fazekas scale and CDR. Cut-points from the accuracy young referent (VCI+ vs. 30-49 yrs VCI-) outperformed the accuracy age-/sex-matched referent (VCI+ vs. age-/sex-matched VCI-), suggesting that older VCI- individuals may have unmeasured CeVD changes. Diffusion MRI markers progressed earlier relative to WMH, highlighting their potential for early detection, improved clinical assessment, and targeted interventions.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_104352
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
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article

Early & late cerebrovascular biomarkers: Operationalization of cut‐points and temporal progression

Mingzhao Hu
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Early & late cerebrovascular biomarkers: Operationalization of cut‐points and temporal progression

Mingzhao Hu
article en

Abstract

We developed cut-points for diffusion MRI markers using classification of VCI based on Fazekas scale and CDR. Cut-points from the accuracy young referent (VCI+ vs. 30-49 yrs VCI-) outperformed the accuracy age-/sex-matched referent (VCI+ vs. age-/sex-matched VCI-), suggesting that older VCI- individuals may have unmeasured CeVD changes. Diffusion MRI markers progressed earlier relative to WMH, highlighting their potential for early detection, improved clinical assessment, and targeted interventions.

Alzheimer s & DementiaVol. 21(S2)
Mayo Clinic in Florida (US)
Openalex Percentile: Top 32%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Early & late cerebrovascular biomarkers: Operationalization of cut‐points and temporal progression — Mingzhao Hu · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS