Neuronal extracellular vesicles biomarkers of Alzheimer's disease in a subset of a longitudinal cohort using plasma

Our findings show evidence of distinct pattern of associations between different pTau species and cognition, suggesting some unique properties of p231-Tau in tracking disease severity in AD. This would suggest that p231-Tau, one of the earliest phosphorylation to occur in the development of AD, may be best suited for monitoring disease activity in AD and for showing response to experimental treatments. Further basic research and application in large cohorts is needed to validate and elucidate the basis of this unique feature.