Regional cortical thinning in amnestic MCI and logopenic primary progressive aphasia for similar symptom duration

For a similar symptom duration, we found significantly thinner cortex in language and AD-related regions in LPA compared to aMCI, predominately in the left hemisphere. Correlations to NP measures were more widely distributed in the LPA group than aMCI. An understanding of brain changes specific to LPA and aMCI will allow better characterization of the neurodegenerative process in relation to rate of disease progression.