Development of Solid Lipid Microparticles From Vitamin C Incorporated Zinc‐Aminoclay for Cosmetic Applications

ABSTRACT This study focused on creating solid lipid microparticles (SLMs) that combine vitamin C (VC) and zinc‐aminoclay (ZnAC) incorporation to improve skincare effectiveness. VC is known for its antioxidant and skin‐brightening benefits, but it can be unstable and is poorly absorbed by the skin. ZnAC, a two‐dimensional material with antimicrobial properties, helps enhance delivery. By encapsulating VC in ZnAC with SLMs, we aimed to boost its stability and skin absorption. We evaluated the physical properties, entrapment efficiency, and stability of these formulations. The results showed that VC‐ZnAC‐SLMs had better skin permeability and stability compared to VC alone and VC combined with ZnAC and SLM. The transdermal absorption of the VC‐ZnAC‐SLM achieved the highest transdermal absorption (2.42%), followed by VC‐ZnAC and pure VC, with the transdermal absorption rates of 1.25% and 1.04%. The unique structure of ZnAC played a key role in these improvements. Our findings suggest that SLMs with ZnAC and VC could be an effective solution for cosmetic products. Practical Applications : The developed VC‐ZnAC‐SLMs offer a practical solution for formulating more effective skincare products, especially those aimed at brightening and protecting the skin. By enhancing vitamin C's stability and absorption, these formulations can provide prolonged antioxidant benefits and improved delivery of skin‐brightening effects. The inclusion of ZnAC further adds antimicrobial protection, which is beneficial for sensitive or acne‐prone skin types. This combination could be applied in serums, creams, and masks, helping consumers achieve better skin health with more reliable, long‐lasting results compared to conventional vitamin C products.