DCE‐MRI reveals reduced BBB permeability in basal forebrain in AD patients
Participants in the AD group had lower mean K-trans in total BF (K-trans<sub>CU</sub>= 0.573 x10<sup>-3</sup>min<sup>-1</sup>; K-trans<sub>AD</sub>= 0.270 x10<sup>-3</sup>min<sup>-1</sup>, p = 0.002), anterior-intermediate (K-trans<sub>CU</sub>= 0.833 x10<sup>-3</sup>min<sup>-1</sup>; K-trans<sub>AD</sub>= 0.291 x10<sup>-3</sup>min<sup>-1</sup>, p = 0.002) and posterior (K-trans<sub>CU</sub> = 0.536 x10<sup>-3</sup>min<sup>-1</sup>; K-trans<sub>AD</sub> = 0.237 x10<sup>-3</sup>min<sup>-1</sup>, p = 0.004) part of nucleus basalis Meynerti. There were no other significant differences between regional BBB permeability in measured structures (p >0.05) CONCLUSION: Our data show regional reduction in BBB permeability BF region but not other regions in patients with MCI due to AD and AD dementia. Regional BBB dysfunction may be one of the factors contributing to early AD related pathological changes in the BF area.
Authors
- Zuzana Nedelská (ORCID: https://orcid.org/0000-0002-3269-2115)
- J. F. HORT
- Jakub Otáhal (ORCID: https://orcid.org/0000-0001-5944-5803)
- Ondřej Lerch (ORCID: https://orcid.org/0000-0002-8030-0905)
- Haris Hadzic
- David Kala (ORCID: https://orcid.org/0009-0007-7035-8939)
Institutions
- Charles University (CZ)
- University Hospital in Motol (CZ)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102261
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00