Inhibitory profile and selectivity of novel ROCK 2 inhibitors: an in‐silico study

Out of the 63 compounds, the top 17 showed promising potency and selectivity for 4 to 19 kinases. The strong performance and selective nature of these compounds make them potential candidates for treating Alzheimer's disease by reducing its symptoms with fewer side effects.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_103089
Primary Topic
Protein Kinase Regulation and GTPase Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

Inhibitory profile and selectivity of novel ROCK 2 inhibitors: an in‐silico study

Kimia Mohammadi
Alzheimer s & Dementia
Protein Kinase Regulation and GTPase Signaling
article

Inhibitory profile and selectivity of novel ROCK 2 inhibitors: an in‐silico study

Kimia Mohammadi
article en

Abstract

Out of the 63 compounds, the top 17 showed promising potency and selectivity for 4 to 19 kinases. The strong performance and selective nature of these compounds make them potential candidates for treating Alzheimer's disease by reducing its symptoms with fewer side effects.

Alzheimer s & DementiaVol. 21(S5)
Razavi University of Islamic Sciences (IR)
Openalex Percentile: Top 36%
Protein Kinase Regulation and GTPase Signaling
DOIOpen Access PDFOpenAlex
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