A Red Eye in an Elderly Patient: A Case Report Highlighting the Importance of Urgent Diagnosis

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a distinct group of autoimmune disorders characterized by necrotizing inflammation of small blood vessels. Three distinct clinical entities are described, including eosinophilic granulomatosis with polyangiitis (EGPA), granulomatosis with polyangiitis (GPA), and microscopic polyangiitis (MPA). GPA often presents as a multi-system inflammatory disease frequently involving the sinuses, kidney, and lung tissue. Ophthalmologic involvement has been described in GPA and is highly important to recognize, especially if presenting as the initial symptom of the disease. Prompt diagnosis and treatment are essential, given the significant morbidity and mortality associated with GPA.

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Publication Details

Journal
Cureus
Published
2025-12-26
DOI
https://doi.org/10.7759/cureus.100117
Primary Topic
Vasculitis and related conditions
Type
article
Field-Weighted Citation Impact
0.00
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article

A Red Eye in an Elderly Patient: A Case Report Highlighting the Importance of Urgent Diagnosis

Deepa Panikkath
Cureus
Vasculitis and related conditions
article

A Red Eye in an Elderly Patient: A Case Report Highlighting the Importance of Urgent Diagnosis

Deepa Panikkath
article en

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a distinct group of autoimmune disorders characterized by necrotizing inflammation of small blood vessels. Three distinct clinical entities are described, including eosinophilic granulomatosis with polyangiitis (EGPA), granulomatosis with polyangiitis (GPA), and microscopic polyangiitis (MPA). GPA often presents as a multi-system inflammatory disease frequently involving the sinuses, kidney, and lung tissue. Ophthalmologic involvement has been described in GPA and is highly important to recognize, especially if presenting as the initial symptom of the disease. Prompt diagnosis and treatment are essential, given the significant morbidity and mortality associated with GPA.

CureusVol. 17(12)
University of California, Los Angeles (US)
Good health and well-being
Openalex Percentile: Top 28%
Vasculitis and related conditions
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