Visualizing lysosomal viscosity in atherosclerosis with a long-wavelength and large Stokes shift fluorescent probe
We developed a viscosity-activated near-infrared (NIR) fluorescent probe, QV-S. This probe features a long emission wavelength (815 nm), a large Stokes shift (135 nm), high viscosity sensitivity (431-fold signal enhancement), and specific lysosome-targeting capability. QV-S allows for not only real-time monitoring of lysosomal viscosity changes in inflammatory and foam cells but also the precise imaging of atherosclerotic plaques in the aortas of ApoE<sup><b>-/-</b></sup> mice.
Authors
- Fanpeng Kong (ORCID: https://orcid.org/0000-0002-4302-3590)
- Junjie Kou
- Chang Xu
- Ruixin Zhang
- Xiaoxuan Shi
- Xue Wu
- Ying Li
- Bo Tang
Institutions
- Shandong Normal University (CN)
- Ministry of Education (ME)
- Laoshan Laboratory
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1039/d5cc06387f
- Primary Topic
- Molecular Sensors and Ion Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00