Relationship between Aβ PET Imaging and Cognitive Test Scores in MCI

This study provides valuable insights into the relationship between Aβ PET imaging and cognitive function in both the (CN) and (MCI) subjects. The correlation between SUVr and olfactory function was insignificant. Olfactory measures such as Identification and Threshold may require further improvement to enhance their utility in AD pathophysiology. Overall, our findings show that higher amyloid beta deposition is linked to poorer cognitive performance in MCI. Our results may offer potential avenues to streamline the Neuropsychological test battery for AD by closely tying most salient metrics to amyloid beta deposition.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103885
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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Relationship between Aβ PET Imaging and Cognitive Test Scores in MCI

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Relationship between Aβ PET Imaging and Cognitive Test Scores in MCI

Sangam Kanekar, Paul J. Eslinger, Jens Will, Prasanna Karunanayaka, Rommy Elyan, Senal Peiris, Katie Geesey, Qing Yang, Anupa Manjitha Ekanayake Mudiyanselage
article en

Abstract

This study provides valuable insights into the relationship between Aβ PET imaging and cognitive function in both the (CN) and (MCI) subjects. The correlation between SUVr and olfactory function was insignificant. Olfactory measures such as Identification and Threshold may require further improvement to enhance their utility in AD pathophysiology. Overall, our findings show that higher amyloid beta deposition is linked to poorer cognitive performance in MCI. Our results may offer potential avenues to streamline the Neuropsychological test battery for AD by closely tying most salient metrics to amyloid beta deposition.

Alzheimer s & DementiaVol. 21(S2)
Pennsylvania State University (US)
Openalex Percentile: Top 32%
Dementia and Cognitive Impairment Research
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