Association of Neuropsychiatric Symptoms with Blood‐Based Biomarkers pTAU181, NFL, and GFAP in Alzheimer's Disease and Mild Cognitive Impairment
Our findings suggest that certain blood-based biomarkers-pTAU181, NFL, and GFAP- are associated with the development of NPS in Alzheimer's Disease. These biomarkers may help shed light on underlying mechanisms and monitor NPS severity. However, further research in larger cohorts and longitudinal studies is needed to confirm these findings and explore causal relationships.
Authors
- Neda Rashidi‐Ranjbar (ORCID: https://orcid.org/0000-0002-2125-1090)
- Simon Graham (ORCID: https://orcid.org/0000-0002-2214-8212)
- Nathan W. Churchill (ORCID: https://orcid.org/0000-0001-8481-2505)
- David G. Munoz (ORCID: https://orcid.org/0000-0001-6027-8870)
- Tom A. Schweizer
- Corinne E. Fischer
- Luis R Fornazzari
- Rahmah IKHLAS
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103663
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00