Whole Brain Measurement of Amyloid Plaques and Neuroinflammation AD Model Mice

This technology is now being disseminated with our BRAIN Initiative-funded iDISCO-based tissue clearing kits and cloud-based quantification pipeline, enabling neuroscientists to easily employ next generation 3D immunohistochemistry for unbiased, complete, and anatomically precise mapping of the efficacy of CNS therapeutics affecting amyloid deposition and neuroinflammation. We thank NIMH for Grant R43MH122070.