Impact of Vascular Risk Burden and ApoE4 on Cognitive Impairment: Insights from a Non‐Demented Southeast Asian Population

In a non-demented Southeast Asian cohort, higher vascular risk factor count heightens the risk of cognitive impairment. While individually HTN, unlike HLD and DM, does not directly impact cognitive syndrome classification, in conjunction with ApoE4, it substantially increases the likelihood of cognitive impairment in midlife. For ApoE4 carriers, aggressive treatment of HTN is imperative to prevent progression of cognitive impairment.