Cognitive heterogeneity of data‐driven phenotypes and associations with ADRD and cerebrovascular biomarkers in the Atherosclerosis Risk in Communities Study
Cognitive heterogeneity is observed even among CU older adults, with lower executive performance associated with cerebrovascular changes and lower memory associated with certain AD-related changes, possibly indicating risk for cognitive progression through distinct pathways.
Authors
- Emily C. Edmonds (ORCID: https://orcid.org/0000-0002-5130-0500)
- Alexandra J. Weigand (ORCID: https://orcid.org/0000-0002-7931-1383)
- Alden L. Gross (ORCID: https://orcid.org/0000-0002-4678-0562)
- James Russell Pike (ORCID: https://orcid.org/0000-0002-6858-620X)
- Caitlin M. Terao (ORCID: https://orcid.org/0000-0002-5506-9625)
- Fareshte R. Erani (ORCID: https://orcid.org/0000-0001-6517-7980)
- Mark W. Bondi (ORCID: https://orcid.org/0000-0002-1742-3451)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
- B Gwen Windham
- Priya Palta
- David S. Knopman
- Katherine J. Bangen
- Rebecca F. Gottesman
Institutions
- University of North Carolina at Chapel Hill (US)
- Alzheimer's Association (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- San Diego State University (US)
- University of Mississippi Medical Center (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- University Memory and Aging Center (US)
- National Institute of Neurological Disorders and Stroke (US)
- Mayo Clinic in Arizona (US)
- National Institute on Aging (US)
- Banner Alzheimer’s Institute
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_104395
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00