Exposure to TBI increases the susceptibility to tau phosphorylation at pT217

These data demonstrate an association between prior exposure to a severe TBI event with elevated amyloid deposition and selective %p-tau217, suggesting an increasing vulnerability to AD progression, but does not appear to coincide with accelerated neurodegeneration in asymptomatic individuals.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_104606
Primary Topic
Traumatic Brain Injury Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Exposure to TBI increases the susceptibility to tau phosphorylation at pT217

Raquel C. Gardner, Jeremy F. Strain, Kyle Womack, Chia‐Ling Phuah et al.
Alzheimer s & Dementia
Traumatic Brain Injury Research
article

Exposure to TBI increases the susceptibility to tau phosphorylation at pT217

Raquel C. Gardner, Jeremy F. Strain, Kyle Womack, Chia‐Ling Phuah, Owen Guo, Nicolas R. Barthélemy, Randall J. Bateman, Tammie L.S. Benzinger, Suzanne E. Schindler, Yingxin He, John C. Morris
article en

Abstract

These data demonstrate an association between prior exposure to a severe TBI event with elevated amyloid deposition and selective %p-tau217, suggesting an increasing vulnerability to AD progression, but does not appear to coincide with accelerated neurodegeneration in asymptomatic individuals.

Alzheimer s & DementiaVol. 21(S2)
St. Joseph's Hospital and Medical Center (US), Washington University in St. Louis (US), Sheba Medical Center (IL), Mallinckrodt (United States) (US), Institute for Neurodegenerative Disorders (US), Hope Center for Neurological Disorders (US), Saint Louis University (US)
Openalex Percentile: Top 30%
Traumatic Brain Injury Research
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Exposure to TBI increases the susceptibility to tau phosphorylation at pT217 — Raquel C. Gardner, Jeremy F. Strain, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS