Data‐driven analysis of longitudinal tau‐PET scans reveals spatial patterns resembling tau accumulation stages

Using a data-driven approach, we identified four distinct patterns of tau accumulation resembling tau staging that were related to age, clinical diagnosis, baseline early AD pathology burden, and APOE genotype. Within the clinical diagnostic groups, participants with a more extensive accumulation pattern had higher baseline AD pathology. These findings are consistent with and add to previous literature that suggests heterogeneity in tau accumulation is associated with several between-participant factors.