Evaluation of [ <sup>3</sup> H]SynVesT‐1 binding parameters in post‐mortem brain tissue from control and Alzheimer's Disease
Initial results show group-wise differences in the B<sub>MAX</sub> of [<sup>3</sup>H]SynVesT-1 in EC, with E-AD subjects showing greater binding signal. This may suggest compensatory mechanisms occurring early in the progression of the disease. This is part of the SV2A PET Project, a program of the FNIH Biomarker Consortium.
Authors
- Declan King
- Lisa Wells
- Scott Gladstein (ORCID: https://orcid.org/0000-0002-0398-7512)
- Laëtitia Lemoine (ORCID: https://orcid.org/0000-0003-0662-7907)
- Amanda Bevis
- Laura Kulagowska
- Martin Sabandal
- Tara L. Spires‐Jones
- Sjoerd J Finnema
- FNIH SV2A Project Team
- David Bonsall
Institutions
- Foundation for the National Institutes of Health (US)
- AbbVie (United States) (US)
- MRC Centre for Regenerative Medicine (GB)
- UK Dementia Research Institute (GB)
- Perceptive Engineering (United Kingdom) (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103316
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91