Bile acids metabolism in symptomatic hand osteoarthritis
Dysregulated BA metabolism, particularly elevated DCA levels, is associated with SHOA. The observation that DCA interacts with SHOA-related gut microbes, together with genes encoding DCA receptors, may help guide future biologically and clinically relevant studies.
Authors
- Z. Wen
- Jiatian Li (ORCID: https://orcid.org/0009-0001-8280-1105)
- C. Zeng
- Haoyu Li
- D. Hunter
- J. Wei
- Tong Yang (ORCID: https://orcid.org/0000-0002-7156-081X)
- Changjun Li (ORCID: https://orcid.org/0000-0002-9942-7690)
- Guanghua Lei
- Dongxing Xie (ORCID: https://orcid.org/0000-0003-2672-4544)
- Kai Zhao
- Wei Li
- Zidan Yang
- Michael Doherty
- Yuqing Zhang
- Ziying Wu
- Weiya Zhang
- Jing Ye
- Yilun Wang
Institutions
- Boston University (US)
- Harvard University (US)
- Central South University (CN)
- University of Nottingham (GB)
- Changsha University (CN)
- Royal North Shore Hospital (AU)
- Massachusetts General Hospital (US)
- Institute for Musculoskeletal Health (AU)
- Arthritis UK (GB)
- Nottingham Biomedical Research Centre (GB)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1002/art.70048
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81