Aβ12‐28P administration alleviates anxiety in an Alzheimer's disease mouse model
These results suggest that Aβ12-28P has an acute anxiolytic effect in both middle-aged and old AD mice. Our finding opens the possibilities to apply the strategy of targeting Aβ pathology for alleviating neuropsychiatric AD symptoms, such as anxiety, and provide insights into a brain region-specific mechanism behind this therapeutic strategy.
Authors
- Arjun V. Masurkar (ORCID: https://orcid.org/0000-0002-2498-2059)
- Tyra Nguyen
- Yvonne Yiru Xu (ORCID: https://orcid.org/0000-0001-5078-0111)
- Shuo Chen (ORCID: https://orcid.org/0000-0002-7990-4947)
- Amy Chen (ORCID: https://orcid.org/0000-0002-1950-1169)
- Dmitri Lyalikov
- Jasper Kamb
- Michael Xiao
- Karen Ha
- Zhuowei Gong
- Zedong Sun
- Fangzheng Tian
- Thomas Wisniewski
- Xiaoyi Yang
- Chris Kim
Institutions
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_105359
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00