Associations between plasma biomarkers and longitudinal neuropsychiatric symptoms across the cognitive spectrum in older adults: findings from the Massachusetts Alzheimer's Disease Research Center
Findings suggest differential plasma biomarker-NPS associations across the early ADRD spectrum, with a central role of p-tau<sup>217</sup> at the stage of MCI. Results also support biomarker signatures of affective vs. overall NPS. Further dissecting plasma biomarker signatures of specific NPS domains will provide insight into the prognostic value of plasma measures in predicting NPS trajectories over the course of ADRD.
Authors
- Hiroko H. Dodge (ORCID: https://orcid.org/0000-0001-7290-8307)
- Jennifer R. Gatchel (ORCID: https://orcid.org/0000-0002-3892-9742)
- Gad Marshall
- Phebe Palmer
- Pia Kivisäkk (ORCID: https://orcid.org/0000-0001-9708-7509)
- Hyun‐Sik Yang
- Chao‐Yi Wu
- Jacqueline Beltran
- Deborah Blacker
- Kexin Yu
- Steven E Arnold
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- McLean Hospital (US)
- Massachusetts General Hospital (US)
- MaineGeneral Medical Center (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_103645
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00