Investigating the Association Between P2Y12 Receptor, SV2A, and Tau Expression in Postmortem AD and Control Brains Using <i>In Vitro</i> Autoradiography

This study demonstrates that SV2A levels decrease while tau accumulations increase in AD brains with [<sup>3</sup>H]UCB-J and [<sup>18</sup>F]MK-6420 respectively, and our data is consistent with in vivo human PET imaging studies of SV2A and tau. We also showed that P2Y12R is decreased in AD brains with [<sup>3</sup>H]PSB-0413. Positive correlation between regional binding of the three tracers was shown in AD patients.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_102328
Citations
1
Primary Topic
Adenosine and Purinergic Signaling
Type
article
Field-Weighted Citation Impact
1.12
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article

Investigating the Association Between P2Y12 Receptor, SV2A, and Tau Expression in Postmortem AD and Control Brains Using In Vitro Autoradiography

Chao Zheng, Neil Vasdev, Ruiqing Ni, Hannah Le et al.
1 citations
Alzheimer s & Dementia
Adenosine and Purinergic Signaling
1.12
article

Investigating the Association Between P2Y12 Receptor, SV2A, and Tau Expression in Postmortem AD and Control Brains Using In Vitro Autoradiography

Chao Zheng, Neil Vasdev, Ruiqing Ni, Hannah Le, Roger Raymond
article en
1 citations

Abstract

This study demonstrates that SV2A levels decrease while tau accumulations increase in AD brains with [<sup>3</sup>H]UCB-J and [<sup>18</sup>F]MK-6420 respectively, and our data is consistent with in vivo human PET imaging studies of SV2A and tau. We also showed that P2Y12R is decreased in AD brains with [<sup>3</sup>H]PSB-0413. Positive correlation between regional binding of the three tracers was shown in AD patients.

Alzheimer s & DementiaVol. 21(S2)
Centre for Addiction and Mental Health (CA), University of Toronto (CA), University of Zurich (CH), ETH Zurich (CH), Institute for Biomedical Engineering (CH)
Good health and well-being
Openalex Percentile: Top 17%
Adenosine and Purinergic Signaling
1.12
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Investigating the Association Between P2Y12 Receptor, SV2A, and Tau Expression in Postmortem AD and Control Brains Using <i>In Vitro</i> Autoradiography — Chao Zheng, Neil Vasdev, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS